Organoids: Tiny brains grown in 3D-printed bioreactor

Scientists from MIT and the Indian Institute of Technology Madras have grown small amounts of self-organizing brain tissue, known as organoids. The work is reported in Biomicrofluidics. The investigators tested their device with organoids derived from human cells. They observed the growing brain organoids with a microscope and were able to successfully follow their growth and development for seven days. The small bit of brain tissue developed a cavity or ventricle surrounded by a self-organizing structure that resembles a developing neocortex. The percentage of cells in the core of the organoid that died during this one-week period was smaller in the 3-D-printed device than in regular culture conditions. The investigators believe that their cell design protects the tiny growing brain.

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