It has long been understood that a parent's DNA is the principal determinant of health and disease in offspring. Yet inheritance via DNA is only part of the story; a father's lifestyle such as diet, being overweight and stress levels have been linked to health consequences for his offspring. This occurs through the epigenome—heritable biochemical marks associated with the DNA and proteins that bind it. But how the information is transmitted at fertilization along with the exact mechanisms and molecules in sperm that are involved in this process has been unclear until now.
A new study from McGill, published recently in Developmental Cell, has made a significant advance in the field by identifying how environmental information is transmitted by non-DNA molecules in the sperm. It is a discovery that advances scientific understanding of the heredity of paternal life experiences and potentially opens new avenues for studying disease transmission and prevention.To determine how information that affects development gets passed on to embryos, the researchers manipulated the sperm epigenome by feeding male mice a folate deficient diet and then tracing the effects on particular groups of molecules in proteins associated with DNA.
They found that diet-induced changes to a certain group of molecules (methyl groups), associated with histone proteins, (which are critical in packing DNA into cells), led to alterations in gene expression in embryos and birth defects of the spine and skull. What was remarkable was that the changes to the methyl groups on the histones in sperm were transmitted at fertilization and remained in the developing embryo.
https://phys.org/news/2021-03-discovery-non-dna-mechanism-involved-transmitting.html
Contribution by "ΣΤΕΝΤΩΡ": Women keep DNA from men they had sex with
A new study from McGill, published recently in Developmental Cell, has made a significant advance in the field by identifying how environmental information is transmitted by non-DNA molecules in the sperm. It is a discovery that advances scientific understanding of the heredity of paternal life experiences and potentially opens new avenues for studying disease transmission and prevention.To determine how information that affects development gets passed on to embryos, the researchers manipulated the sperm epigenome by feeding male mice a folate deficient diet and then tracing the effects on particular groups of molecules in proteins associated with DNA.
They found that diet-induced changes to a certain group of molecules (methyl groups), associated with histone proteins, (which are critical in packing DNA into cells), led to alterations in gene expression in embryos and birth defects of the spine and skull. What was remarkable was that the changes to the methyl groups on the histones in sperm were transmitted at fertilization and remained in the developing embryo.
https://phys.org/news/2021-03-discovery-non-dna-mechanism-involved-transmitting.html
Contribution by "ΣΤΕΝΤΩΡ": Women keep DNA from men they had sex with
https://www.deccanchronicle.com/lifestyle/sex-and-relationship/270617/find-out-how-women-keep-dna-from-men-she-has-had-sex-with.html
ReplyDeletehttps://www.forbes.com/sites/quora/2017/08/15/male-dna-is-often-found-in-womens-brains-where-does-it-come-from/?sh=1ebb34c17459
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726892/
ΤΑ ΛΕΓΑΜΕ ΠΡΙΝ ΧΡΟΝΙΑ.Ο ΚΟΥΡΗΤΗΣ ΕΙΧΕ ΑΝΑΦΕΡΕΙ ΠΑΛΑΙΟΤΕΡΑ ΚΑΤΙ ΑΝΑΛΟΓΟ,ΝΟΜΙΖΩ ΠΕΡΙ "ΓΛΙΤΣΑΣ"...ΚΑΠΩΣ ΕΤΣΙ ΜΙΑ ΓΥΝΑΙΚΑ ΚΑΤΑΣΤΡΕΦΕΤΑΙ ΠΡΩΤΑ ΣΩΜΑΤΙΚΩΣ (ΚΑΤΑΝΤΩΝΤΑΣ "ΜΠΟΥΡΙ") ΚΑΙ ΕΠΕΙΤΑ ΨΥΧΙΚΩΣ.ΓΙ'ΑΥΤΟ, ΠΡΟΣΟΧΗ ΜΕ ΠΟΙΕΣ ΑΠΟΦΑΣΙΖΕΤΕ ΝΑ ΠΕΡΑΣΕΤΕ ΤΟ ΥΠΟΛΟΙΠΟ ΤΟΥ ΒΙΟΥ ΣΑΣ.
ΕΠΙΣΗΣ ΝΑ ΘΥΜΑΣΤΕ ΠΩΣ ΥΠΕΡΙΣΧΥΕΙ ΤΟ ΣΠΕΡΜΑ ΤΟΥ ΓΕΝΕΤΙΚΑ ΔΥΝΑΤΟΤΕΡΟΥ.ΑΥΤΟ ΓΙΑ ΟΣΟΥΣ ΕΧΟΥΝ ΑΜΦΙΒΟΛΙΕΣ ΠΕΡΙ ΤΗΣ ΓΕΝΕΤΙΚΗΣ ΚΑΘΑΡΟΤΗΤΟΣ ΤΩΝ ΤΕΚΝΩΝ ΤΟΥΣ.
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